CNS/Neuroscience

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Scotland has particular expertise in the areas in neuroscience of cognition and dementia, neurodevelopmental and mental health disorders, neurodegenerative disorders,  neuroinformatics, stroke and brain imaging.

Major research studies and activities in neurodegenerative disorders which are currently underway or recently completed include:

  • The University of Edinburgh Multiple Sclerosis research centre and Anne Rowling Regenerative Neurology Clinic provides world-class research under the co-direction of Professor Charles ffrench-Constant, Professor of Professor of Multiple Sclerosis Research and Professor Siddhathan Chandran, Professor of Neurology. The clinic will focus on patient-based studies to help find treatments that could slow the progression of MS and other progressive, incurable diseases such as Motor Neurone Disease, Alzheimer's disease, Parkinson's disease and Huntington's disease. 
  •  The Euan MacDonald Centre for Motor Neurone Disease Research is led by Professor Siddharthan Chandran, a neurologist and researcher, and incorporates the multidisciplinary specialist NHS MND clinic at the Royal Infirmary of Edinburgh. The Euan MacDonald Centre brings together researchers from across the University of Edinburgh to form a unique focal point for MND patients in Scotland.

Scotland has a number of active research groups undertaking leading edge research in the Transmissible Spongiform Encephalopathies (TSEs) or Prion Diseases.  Research studies currently underway include:

  • Blood transfusion as a route of transmission of prion diseases led by Professor Jean Manson and Dr Robert Will
  • Identifying and defining new human TSEs led by Professor Jean Manson, Professor James Ironside  and Dr Robert Will
  • Assessing zoonotic potential of animal prions lead by Dr Rona Barron
  • Developing diagnostic tests for prion disease  lead by Dr Mark Head
  • Biomarkers for prion disease lead by Dr Alison Green
  • Defining mechanisms of neurodegeneration in prion disease and Alzheimers disease lead by Professor Jean Manson
  • Defining the impact of viral infection on chronic neurodegeneration lead by Professor Jean Manson
  • Defining the cellular routes of prion neuroinvasion lead by Dr Neil Mabbott
  • Understanding the mechanisms by which specific proteins misfold and lead to disease by Dr Andy Gill
  • The Scottish TSE Research Network chaired by Jean Manson provides a range of supports which further improve the quality and quantity of health research in this area as well as continue to ensure all appropriate research infrastructure and expertise is in place to allow effective delivery of research programmes.
  • Leading researchers in neurodegenerative disorders include Dr Robert Will, Professor James Ironside, Professor Richard Knight, Dr Mark Head, Dr Alison Green, Dr Matthew Bishop, Professor Jean Manson, Dr Rona Barron, Dr Neil Mabbot, Dr Wilfred Goldmann and Dr Nora Hunter, Professor Hugh Willison, Professor Siddharthan Chandran, Professor Charles ffrench-Constant,

Neuroscience research in Scotland takes advantage of a number of key assets and infrastructures, including:



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